49. C. Lung cancer prevention. LDL was isolated from plasma by ultracentrifugation. Lipids (1998): 981-984. However, a diet high in olive oil and rich in lycopene may decrease the risk of coronary heart disease by improving the serum lipid profile compared with a high-carbohydrate, low-fat, lycopene-rich di … Le lycopène et le bêta-carotène étant très semblables, ceci laisse donc entendre que le lycopène est nocif. An Optical Density (OD) of 1 = 3.1206 µg of lycopene per mL. The effect of lycopene on macrophage foam cell formation induced by modified low-density lipoprotein (LDL) was studied. Plasma antioxidants and cognitive performance in middle-aged … ↑ Bub A, Watzl B, Abrahamse L, et al. Through several desaturation steps, phytoene is converted into lycopene. Tomato lycopene and β-carotene inhibit low density lipoprotein oxidation and this effect depends on the lipoprotein vitamin E content Lycopene is an open chain unsaturated carotenoid that gives tomatoes, guava, rose hip, watermelon and pink grapefruit its red color. Each extension in this conjugated system reduces the energy required for electrons to transition to higher energy states, allowing the molecule to absorb visible light of progressively longer wavelengths. [26] Because lycopene may cause low blood pressure, interactions with drugs that affect blood pressure may occur. [3][24] Some foods that do not appear red also contain lycopene, e.g., asparagus, which contains about 30 μg of lycopene per 100-g serving[3] (0.3 μg/g) and dried parsley and basil, which contain around 3.5–7.0 μg/g of lycopene. Stage 1 hypertensive subjects. It is found in tomatoes, watermelon and papaya. Available research suggests that doses of more than 25 milligrams of lycopene daily may lower levels of low-density lipoprotein (LDL, or “bad”) cholesterol and total cholesterol. ↑ Erdman JW Jr, Ford NA, Lindshield BL. Two different mean particle sizes (80 and 345 μm) were used at two solvent flow rates (0.792 and 1.35 kg/h). In the present work, the effect of lycopene on copper induced oxidation of isolated low‐density lipoprotein (LDL) and the related mechanism were investigated. Increase in low density lipoprotein (LDL) oxidation is hypothesized to be causally associated with increasing risk of atherosclerosis and coronary heart disease. Human monocyte-derived macrophages (HMDM) were incubated with lycopene in the presence or absence of native LDL (nLDL) or LDL modified by oxidation (oxLDL), aggregation (aggLDL), or acetylation (acLDL). [4][22], Cooking and crushing tomatoes (as in the canning process) and serving in oil-rich dishes (such as spaghetti sauce or pizza) greatly increases assimilation from the digestive tract into the bloodstream. Tomato and tomato products are rich sources of lycopene. Keywords: lycopene intake, bone mineral density, bone resorption, bone formation, oxidative stress. [4] Ketchup is a common dietary source of lycopene. CC(=CCC/C(=C/C=C/C(=C/C=C/C(=C/C=C/C=C(/C=C/C=C(/C=C/C=C(/CCC=C(C)C)\C)\C)\C)/C)/C)/C)C [4] When exposed to light or heat, lycopene can undergo isomerization to any of a number of cis-isomers, which have a bent rather than linear shape. Formulated products containing more than just tomatoes can also be analyzed using this procedure but only with care. Lycopene, CAS: 502-65-8, is a highly conjugated antioxidant carotenoid compound. Increase in low density lipoprotein (LDL) oxidation is hypothesized to be causally associated with increasing risk of atherosclerosis and coronary heart disease. [4], Lycopene is not an essential nutrient for humans, but is commonly found in the diet mainly from dishes prepared from tomatoes. Gac has high lycopene content derived mainly from its seed coats. Supplementation with tomato juice increases plasma lycopene but does not alter susceptibility to oxidation of low-density lipoproteins from renal transplant recipients. acentric factor. March 26, 2016. 48. An acyclic carotene commonly obtained from tomatoes and other red fruits. [27] A 2010 review concluded that research has been insufficient to establish whether lycopene consumption affects human health. Research suggests that increased lycopene intake may reduce the risk of lung cancer. In early 2009, one study found 10 milligrams of lyocpene per day helps maintain bone density compared to taking only 3 milligrams per day (8) while another study in the same month found 12 milligrams of lycopene per day to be superior to 4 milligrams per day for bone health (9). Lycopene is a lipid-soluble carotenoid that exists in both all-trans and cis-configurations in nature. Abstract The molecular structural and Raman spectroscopic characteristics of β‐carotene and lycopene are investigated by density functional calculations. [4] Although gac (Momordica cochinchinensis Spreng) has the highest content of lycopene of any known fruit or vegetable (multiple times more than tomatoes),[17][18] tomatoes and tomato-based sauces, juices, and ketchup account for more than 85% of the dietary intake of lycopene for most people. Effect of lycopene on the copper-induced oxidation of low-density lipoprotein in broiler chickens. Increase in low density lipoprotein (LDL) oxidation is hypothesized to be causally associated with increasing risk of atherosclerosis and coronary heart disease. Lycopene (molecular formula: C40H56) is a linear, unsaturated hydrocarbon carotenoid, the major bright red pigment, a phytochemical found in fruits such as tomatoes and other red fruits such as papaya, pink grapefruit, apricots, red oranges, watermelon, rosehips and guavas 3).Lycopene is the most common carotenoid in the human body and is one of the most potent … It is insoluble in plain water, but it can be dissolved in organic solvents and oils. Tomato lycopene and low density lipoprotein oxidation: a human dietary intervention study. ↑ Erdman JW Jr, Ford NA, Lindshield BL. 1997;146(8):618-626.9345115. Lycopene-containing foods are often healthier options in our diet as colorful foods like tomatoes are known to help prevent cancer. [3] Although lycopene is chemically a carotene, it has no vitamin A activity. Stability: Heat sensitive - store at -70 C. Combustible. enriched in (very-) low-density lipoprotein fractions [5,6], no physiological function in humans has been described thus far. 1. There are various benefits of lycopene; it helps in reducing risk of certain types of cancers, heart disease and macular degeneration. ", InChI=1S/C40H56/c1-33(2)19-13-23-37(7)27-17-31-39(9)29-15-25-35(5)21-11-12-22-36(6)26-16-30-40(10)32-18-28-38(8)24-14-20-34(3)4/h11-12,15-22,25-32H,13-14,23-24H2,1-10H3/b12-11+,25-15+,26-16+,31-17+,32-18+,35-21+,36-22+,37-27+,38-28+,39-29+,40-30+, InChI=1/C40H56/c1-33(2)19-13-23-37(7)27-17-31-39(9)29-15-25-35(5)21-11-12-22-36(6)26-16-30-40(10)32-18-28-38(8)24-14-20-34(3)4/h11-12,15-22,25-32H,13-14,23-24H2,1-10H3/b12-11+,25-15+,26-16+,31-17+,32-18+,35-21+,36-22+,37-27+,38-28+,39-29+,40-30+, C(\C=C\C=C(\CC/C=C(\C)C)C)(=C/C=C/C(=C/C=C/C=C(/C=C/C=C(/C=C/C=C(\C)CC\C=C(/C)C)C)C)C)C, Except where otherwise noted, data are given for materials in their, Regulatory status in Europe and the United States, Australia New Zealand Food Standards Code, "Foods highest in lycopene, Nutrition Data, USDA Nutrient Database, version SR-21", "Carotenoids: α-Carotene, β-Carotene, β-Cryptoxanthin, Lycopene, Lutein, and Zeaxanthin", "Standard 1.2.4 – Labelling of ingredients", "Current EU approved additives and their E Numbers", "Light-Harvesting Function of β-Carotene Inside Carbon Nanotubes", "How To Clean Tomato Sauce Stains From Plastic Storage Containers", "Gac (Momordica cochinchinensis) Analysis report", "Effects of maturity on physicochemical properties of Gac fruit (Momordica cochinchinensis Spreng. J Nutr. [13] Lycopene extraction from tomatoes, as a promising health-promoting functional food ingredient, is drawing increasing attention by the food industry. ↑ Bub A, Watzl B, Abrahamse L, et al. [4] It is insoluble in water. Full Text PDF [647K] Abstracts References(38) Cited-By(2) Intake of the antioxidant lycopene has been reported to decrease oxidative stress and have beneficial effects on bone health. Because of its lipophilic nature, lycopene concentrates in low-density and very-low-density lipoprotein fractions of the serum. Lycopene absorbs all but the longest wavelengths of visible light, so it appears red. Lycopene is a lipid-soluble carotenoid that exists in both all-trans and cis-configurations in nature. Compare Products: Select up to 4 products. Lipids. The dual wavelength procedure should be used and the density of the material checked if the sample is to be added by volume. [7], Lycopene is a symmetrical tetraterpene assembled from eight isoprene units. Laboratory of Poultry Nutrition, Department of Animal Science and Technology, College of Animal Bioscience and Technology, Konkuk University. [21] Processed tomato products such as pasteurized tomato juice, soup, sauce, and ketchup contain a higher concentration of bioavailable lycopene compared to raw tomatoes. CopyCopied, CSID:394156, http://www.chemspider.com/Chemical-Structure.394156.html (accessed 20:03, Jan 7, 2021) [4], Plants and photosynthetic bacteria naturally produce all-trans lycopene. 15-cis-phytoene + 4 an oxidized electron acceptor -> all-trans-lycopene + 4 a reduced electron acceptor, 15-cis-phytoene + 5 an oxidized electron acceptor -> all-trans-3,4-didehydrolycopene + 5 a reduced electron acceptor, all-trans-zeta-carotene + 2 an oxidized electron acceptor -> all-trans-lycopene + 2 a reduced electron acceptor, trans-lycopene biosynthesis II (oxygenic phototrophs and green sulfur bacteria), all-trans neurosporene + an oxidized electron acceptor -> all-trans-lycopene + a reduced electron acceptor, all-trans-lycopene + 2 oxygen -> 2 sulcatone + bixin aldehyde, all-trans-lycopene + 2 oxygen -> 4,9,13-trimethyltetradeca-2,4,6,8,10,12-hexaene-1,14-dial + pseudoionone + geranial, all-trans-lycopene + 2 oxygen -> 4,9-dimethyldodeca-2,4,6,8,10-pentaene-1,12-dial + 2 pseudoionone, all-trans-lycopene + 2 oxygen -> bixin aldehyde + 2 sulcatone, all-trans-lycopene + 2 oxygen -> pseudoionone + 4,8,13-trimethylhexadeca-heptaenedial + sulcatone, all-trans-lycopene + an oxidized electron acceptor -> all-trans-3,4-didehydrolycopene + a reduced electron acceptor. 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